This guide was created to simplify, yet cover in detail, the most COMMON workups and diseases seen in the field of Internal Medicine. It is perfect for any 3rd or 4th year medical student, intern or resident, physician assistant, nurse practitioner, or even attending. It is designed to be small enough to bring with you to work to use as a reference book, but also to be used as a study tool for high yield testing points. It starts with common symptoms and their workups and management, such as shortness of breath and chest pain amongst others. The most common diagnoses seen are then explored, and the text dives into the approach to the history/physical, differential, labs/imaging, diagnostic/treatment algorithms, treatment, etiologies, risk factors, pathogenesis, complications, prevention, and general admission orders. Miscellaneous topics (chest X-ray reading, EKGs, etc.) and basic ICU topics (shock, vasopressors, DKA, etc.) are explained, as well as common medications prescribed. All the material is evidenced based (with references to clinical trials) with sources used including Uptodate, Harrisons Principals to Internal Medicine 19th Edition, Pocket Medicine 5th Edition, MKSAP 17, and Online MedEd amongst others. I hope this guide is helpful to you in your training and beyond.